People

Sen Song Ph.D.

Principal investigator, Department of Biomedical Engineering, Tsinghua University  Assistant Director of Brain and Intelligence Laboratory of Tsinghua University

Since my childhood, I have been fascinated by two questions:1) why human can do intelligent things that computers cannot do, and 2) what is a good life. I am glad to find out that I can tackle these fundamental questions with the tools provided by modern neuroscience, particularly because the interdisciplinary nature of brain research provides many exciting avenues to pursue their answers. Since coming to Tsinghua, I have also been increasingly interested in brain related medical problems, like depression and anxiety disorders. The overarching theme in my lab is what I call connectomics and functional connectomics: we take inspirations from genomics and functional genomics to arrive at a circuit diagram of the brain. Our work uncovers the relations between circuit structures and functions to elucidate the computational processes carried out by those circuits. Current research includes:
1. Combining the knowledge of brain science, cognitive science and artificial intelligence to construct a whole brain functional computational model. Our aim is to build brain-inspired novel artificial intelligence algorithms, and to apply them on brain-inspired computing chips.
2. Using imaging, optogenetics, and EEG to study the neural basis of advanced cognitive functions such as positive emotions and motivation, aesthetics, semantic understanding, thinking and reasoning.
3 Using quantitative methods, artificial intelligence algorithms, and brain feedback techniques for diagnoses and treatment of emotional disorders, as well as to improve the quality of life and well-being of normal people.
4. Using artificial intelligence algorithms such as deep learning, especially graph neural network technology, to develop new computing tools to analyze the large amount of data generated by connectomics, genomics, and brain imaging technologies.

Degrees

Brandeis University, Ph.D., 2002

University of Mississippi, B.A., 1996

Appointments

Tsinghua University Medical School, Principal Investigator, 2010 - current

Massachusetts Institute of Technology, Postdoctoral Fellow, 2004 - 2010

Cold Spring Harbor Laboratory, Postdoctoral Fellow, 2002 – 2004

GPC Biotech, Computational Biologist, 2001 – 2002

Selected Publications

Pei, J.#, Deng, L.#, Song, S.#, Zhao, M.#, Zhang, Y.#, Wu, S.#, Wang, G.#,…&Shi, L. *(2019).Towards artificial general intelligence with hybrid Tianjic chip architecture. Nature, 572, 106–111.

Liao, F., Liang, M., Li, Z., Hu, X.*, & Song, S.* (2019). Evaluate the Malignancy of Pulmonary Nodules Using the 3-D Deep Leaky Noisy-or Network. IEEE transactions on neural networks and learning systems.

Chen, C., Cheng, M., Ito, T.*, & Song, S.* (2018). Neuronal organization in the inferior colliculus revisited with cell-type-dependent monosynaptic tracing. Journal of Neuroscience, 38(13), 3318-3332.

Liu, X., Mou, L., Cui, H., Lu, Z.*, & Song, S.* (2018). Jumper: Learning when to make classification decisions in reading. arXiv preprint arXiv:1807.02314. IJCAI 2018

Liao, F., Chen, X., Hu, X. *, & Song, S.* (2017). Estimation of the volume of the left ventricle from MRI images using deep neural networks. IEEE transactions on cybernetics, 49(2), 495-504.

Zhu, C.#, Yao, Y.#, Xiong, Y., Cheng, M., Chen, J., Zhao, R., ... & Song, S.* (2017). Somatostatin neurons in the basal forebrain promote high-calorie food intake. Cell reports, 20(1), 112-123.

Zhao, Z., Wang, L., Gao, W., Hu, F., Zhang, J., Ren, Y., Lin, R. Feng, Q., Cheng, M., Ju, D., Chi, Q., Wang, D., Song, S., Luo, M., Zhan, C.* (2017). A central catecholaminergic circuit controls blood glucose levels during stress. Neuron, 95(1), 138-152.

Li, X., Steffens, D. C., Potter, G. G., Guo, H., Song, S., & Wang, L.* (2017). Decreased between‐hemisphere connectivity strength and network efficiency in geriatric depression. Human brain mapping, 38(1), 53-67.

Wang, Q., Zhang, J., Song, S.*, & Zhang, Z.* (2014). Attentional neural network: Feature selection using cognitive feedback. In Advances in Neural Information Processing Systems (pp. 2033-2041).

Sümbül, U. #, Song, S. #, McCulloch, K., Becker, M., Lin, B., Sanes, J. R., ... & Seung, H. S.* (2014). A genetic and computational approach to structurally classify neuronal types. Nature communications, 5, 3512.

Grillo, F. W., Song, S.*, Ruivo, L. M. T. G., Huang, L., Gao, G., Knott, G. W., ... & De Paola, V.* (2013). Increased axonal bouton dynamics in the aging mouse cortex. Proceedings of the National Academy of Sciences, 110(16), E1514-E1523.

Song, S.#, Liu, L.#, Edwards, S. V., & Wu, S.* (2012). Resolving conflict in eutherian mammal phylogeny using phylogenomics and the multispecies coalescent model. Proceedings of the National Academy of Sciences, 109(37), 14942-14947.

Song, S., Sjöström, P. J., Reigl, M., Nelson, S., & Chklovskii, D. B.* (2005). Highly nonrandom features of synaptic connectivity in local cortical circuits. PLoS biology, 3(3), e68.

Song, S., Miller, K. D., & Abbott, L. F.* (2000). Competitive Hebbian learning through spike-timing-dependent synaptic plasticity. Nature neuroscience, 3(9), 919.

Contact Information

Email: songsen@tsinghua.edu.cn

Office: No. 160, Chengfu Road, Haidian District, Beijing

Phone: +86-10-62773357

Webpage: http://www.ncbi.nlm.nih.gov/pubmed/?term=Song+Sen%5BAuthor+-+Full%5D