Yichang Jia Ph.D.
Principle Investigator, School of Medicine, Tsinghua University
One of the major questions in neuroscience field is the disease mechanisms underlying neurodegenerative disorders, which afflict millions of people worldwide, but so far almost no effective cure has been developed for these devastating disorders, partially due to our poor understanding of disease mechanisms. Because mouse shares over 90% gene similarity with human, to study chemical-induced mutant mice carrying neurodegenerative phenotypes greatly enhances our knowledge on the disease mechanisms and accelerates the speed in identification of novel therapeutic interventions. In addition, with the advance of gene editing technologies, we are able to generate the knock-in mutant mice carrying the disease mutations to better model diseases and understand the underlying mechanisms. Our long-term goal is to bridge our basic research into the therapeutic target discoveries by combining molecular biology and mouse genetics.
Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Ph.D., 2006
Nanjing Medical University, M.S., 2001
Nanjing Medical University, B.S., 1994
The Howard Hughes Medical Institute, Postdoctoral Fellow, 2007 – 2012
McGovern Institute for Brain Research at Tsinghua University, Tsinghua-Peking Join Center for Life Sciences, Principal Investigator, 2013 - current
Tsinghua University, Assistant Professor, 2013 – 2017
Tsinghua University, Associate Professor, 2017 – now
Jiaofeng Chen, Xue Zhang, Jie Li, Chenmeng Song, Yichang Jia*, Wei Xiong. Identification of a Novel ENU-Induced Mutation in Mouse Tbx1 Linked to Human DiGeorge Syndrome. Neural Plasticity. Volume, 1(5836143) (2016).
Yichang Jia, Tom Jucius, Susan Cook, Susan Ackerman. Loss of Clcc1 Results in ER Stress, Misfolded Protein Accumulation, and Neurodegeneration. Journal of Neuroscience, 2.18, 35(7): 3001~3009 (2015).
Yichang Jia*, John Mu, Susan Ackerman. Mutation of a U2 snRNA Gene Causes Global Disruption of Alternative Splicing and Neurodegeneration. Cell. 148, 296-308 (2012).
Jian Zhou, Wanlu Du, Kechun Zhou, Yilin Tai, Hanlan Yao, Yichang Jia, Yuqiang Ding, Yizheng Wang. Critical role of TRPC6 channels in the formation of excitatory synapses. Nature Neuroscience. 11, 741-3 (2008).
YiqunYao, Xia Ding, Yichang Jia, Chuanxin Huang, Yizheng Wang, and Yunhui Xu. Anti-tumor effect of b-elemene in glioblastoma cells 3 depends on p38 MAPK activation. Cancer Lett. 264, 127-134 (2008).
Zenghua Wang, Bin Shen, Haolan Yao, Yichang Jia, Jing Ren, Youji Feng and Yizheng Wang. Blockage of intermediate-conductance-Ca2+-activated K+ channels inhibits progression of human endometrial cancer. Oncogene. 26, 5107-5114 (2007).
Chuanxin Huang, Yichang Jia, Shenglian Yang, Biao Chen, Hongwei Sun, Feng Shen and Yizheng Wang. Characterization of ZNF23, a KRAB-containing protein that is downregulated in human cancers and inhibits cell cycle progression. Exp. Cell Res. 313, 254-263 (2007).
Yichang Jia*, Jian Zhou*, Yilin Tai and Yizheng Wang. TRPC channels promote cerebellar granule neuron survival. Nature Neuroscience. 10, 559-567 (2007).
Yan Li*, Yichang Jia*, Kai Cui*, Ning Li, Zai-Yu Zheng, Yi-Zheng Wang and Xiao-Bing Yuan. Essential role of TRPC channels in the guidance of nerve growth cones by brain-derived neurotrophic factor. Nature. 434, 894-898 (2005).
Office: RM D204, Cheng Yu-tung Med BLDG, Tsinghua University, Beijing, China, 100084